Codeine — Drug Interactions, Alcohol & Pregnancy Guide

Last reviewed: · Source: US FDA drug label database

About Codeine

Codeine is a mild opioid painkiller available over-the-counter in low-dose combination products (e.g. co-codamol 8/500) and on prescription in higher doses. It converts to morphine in the liver.

Also sold as: Codeine phosphate, Paracodol (with paracetamol), Nurofen Plus (with ibuprofen)

Drug class Opioid analgesic
Used for Moderate to severe pain, Cough suppression, Diarrhoea
Max adult dose 30-60mg every 4 hours, maximum 240mg in 24 hours
OTC in UK Yes

Codeine and Alcohol

🔴 AVOID

Avoid — codeine and alcohol together cause dangerous respiratory depression and significantly increase overdose risk.

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Codeine in Pregnancy

🔴 AVOID

Avoid codeine in pregnancy — it can cause neonatal opioid withdrawal syndrome and respiratory depression in the newborn if used near delivery.

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Codeine — Drug Combinations

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