Drug Interactions — Can I Take Two Medicines Together?
Find out if two medications can safely be taken together. Every page gives you a clear verdict — Safe, Caution, or Avoid — based on FDA drug label data, in plain English.
Last reviewed:
⭐ Recommended: Manage your medications safely with these essentials — used by thousands of people on complex medication plans.
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Ibuprofen + Paracetamol
Generally safe
Yes — ibuprofen and paracetamol can safely be taken together and are often recommended in combinatio…
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Aspirin + Ibuprofen
Use with caution
Generally avoid — ibuprofen can reduce the blood-thinning effect of low-dose aspirin and both drugs …
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Codeine + Ibuprofen
Generally safe
Generally safe — ibuprofen and codeine are often combined deliberately in products like Nurofen Plus…
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Codeine + Paracetamol
Generally safe
Yes — paracetamol and codeine are commonly combined in co-codamol, a standard NHS prescription paink…
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Aspirin + Warfarin
Avoid
Avoid — aspirin significantly increases bleeding risk when taken with warfarin and can cause serious…
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Ibuprofen + Warfarin
Avoid
Avoid — ibuprofen increases bleeding risk and can significantly raise warfarin levels, increasing ha…
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Diazepam + Sertraline
Use with caution
Use with caution — sertraline and diazepam can both cause sedation and are sometimes prescribed toge…
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Sertraline + Tramadol
Avoid
Avoid — combining sertraline and tramadol carries a serious risk of serotonin syndrome, a potentiall…
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Fluoxetine + Tramadol
Avoid
Avoid — fluoxetine and tramadol is a high-risk combination for serotonin syndrome and is also associ…
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Ibuprofen + Metformin
Use with caution
Use with caution — ibuprofen can affect kidney function, which may cause metformin to accumulate to …
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Codeine + Diazepam
Avoid
Avoid — codeine and diazepam together can cause dangerous respiratory depression, particularly in th…
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Paracetamol + Tramadol
Generally safe
Generally safe — tramadol and paracetamol are often combined in the prescription product Tramacet fo…
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Diazepam + Zopiclone
Avoid
Avoid — diazepam and zopiclone together cause additive CNS and respiratory depression, substantially…
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Pregabalin + Tramadol
Use with caution
Use with caution — pregabalin and tramadol can increase drowsiness and dizziness when used together …
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Gabapentin + Tramadol
Use with caution
Use with caution — gabapentin and tramadol can increase sedation and are associated with increased o…
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Amoxicillin + Ibuprofen
Generally safe
Generally safe — ibuprofen and amoxicillin do not interact significantly and can be taken together f…
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Naproxen + Ibuprofen
Avoid
Do not take naproxen and ibuprofen together — they are both NSAIDs and combining them doubles your r…
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Naproxen + Paracetamol
Generally safe
Naproxen and paracetamol can safely be taken together at standard doses — they work in different way…
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Omeprazole + Clopidogrel
Use with caution
Omeprazole can make clopidogrel less effective at preventing clots — the FDA advises avoiding this c…
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Atorvastatin + Clarithromycin
Avoid
Clarithromycin dramatically raises atorvastatin levels, increasing the risk of severe muscle damage …
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Sertraline + Ibuprofen
Use with caution
Sertraline combined with ibuprofen significantly increases the risk of stomach bleeding — occasional…
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Levothyroxine + Omeprazole
Use with caution
Long-term omeprazole can reduce levothyroxine absorption — take levothyroxine on an empty stomach an…
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Bisoprolol + Amlodipine
Generally safe
Bisoprolol and amlodipine are commonly prescribed together for blood pressure and angina — the combi…
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Ramipril + Ibuprofen
Use with caution
Ibuprofen can blunt ramipril's blood-pressure control and, combined with dehydration or a diuretic, …
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Citalopram + Omeprazole
Use with caution
Omeprazole raises citalopram blood levels, which increases the risk of QT heart-rhythm changes — the…
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Amoxicillin + Paracetamol
Generally safe
Amoxicillin and paracetamol are safe to take together — this is the standard combination for treatin…
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Gabapentin + Codeine
Avoid
Gabapentin combined with codeine or other opioids significantly increases the risk of respiratory de…
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Zopiclone + Codeine
Avoid
Zopiclone plus codeine combines two central nervous system depressants — the pairing risks dangerous…
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Propranolol + Sertraline
Use with caution
Propranolol and sertraline are often prescribed together for anxiety — the combination is generally …
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Doxycycline + Ibuprofen
Generally safe
Doxycycline and ibuprofen have no significant interaction — you can take ibuprofen for pain or fever…
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Prednisolone + Ibuprofen
Use with caution
Prednisolone plus ibuprofen substantially raises the risk of stomach ulcers and bleeding — avoid reg…
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Warfarin + Paracetamol
Use with caution
Paracetamol is the safest painkiller on warfarin, but regular use (more than a few days) can raise y…
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Metformin + Omeprazole
Generally safe
Metformin and omeprazole are safe to take together — millions of people with diabetes and reflux use…
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Cetirizine + Loratadine
Use with caution
Cetirizine and loratadine do the same job — doubling up gives little extra benefit and more drowsine…
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Salbutamol + Propranolol
Avoid
Propranolol directly blocks salbutamol's action and can itself trigger life-threatening bronchospasm…
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Fluoxetine + Ibuprofen
Use with caution
Fluoxetine plus ibuprofen raises stomach-bleeding risk several-fold — fine occasionally for most hea…
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Lansoprazole + Levothyroxine
Use with caution
Like all PPIs, lansoprazole can reduce levothyroxine absorption over time — separate the doses and r…
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Tamsulosin + Sildenafil
Use with caution
Tamsulosin and sildenafil can be used together but both lower blood pressure — separate dosing by at…
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Montelukast + Cetirizine
Generally safe
Montelukast and cetirizine are safe and often deliberately combined for allergies and allergic asthm…
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Amlodipine + Simvastatin
Use with caution
Amlodipine raises simvastatin levels — the FDA caps simvastatin at 20mg daily when combined with aml…