Duloxetine — Drug Interactions, Alcohol & Pregnancy Guide

Last reviewed: · Source: US FDA drug label database

About Duloxetine

Duloxetine is an SNRI antidepressant also used for nerve pain and anxiety. Unlike other SSRIs, it carries a specific liver toxicity warning with alcohol use. Avoid substantial alcohol use with duloxetine.

Also sold as: Cymbalta, Yentreve

Drug class SNRI (Serotonin-Noradrenaline Reuptake Inhibitor)
Used for Depression, Generalised anxiety disorder, Neuropathic pain, Fibromyalgia, Stress urinary incontinence
Max adult dose 60-120mg once daily
OTC in UK Prescription only

Duloxetine and Alcohol

🔴 AVOID

Avoid alcohol with duloxetine — the combination increases liver enzyme levels and may cause liver damage, in addition to worsening depression.

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