Can You Take Metronidazole with Alcohol?
Last reviewed: · Source: US FDA drug label database
Never drink alcohol with metronidazole — the combination causes a severe disulfiram-like reaction with vomiting, flushing, rapid heart rate, and severe distress.
Is it safe to take Metronidazole with Alcohol?
Metronidazole and alcohol have one of the most well-known dangerous drug-alcohol interactions. Combining them causes a disulfiram-like reaction (similar to the drug Antabuse) characterised by intense flushing, severe nausea and vomiting, headache, rapid heart rate, and a profound feeling of illness. This is not just unpleasant — it can be dangerous, particularly in people with heart conditions. You must completely avoid alcohol during your course of metronidazole and for at least 48 hours after the last dose.
How do Metronidazole and Alcohol interact?
Metronidazole inhibits aldehyde dehydrogenase (ALDH2), the enzyme responsible for converting acetaldehyde to acetic acid in alcohol metabolism. When alcohol is ingested with metronidazole, acetaldehyde accumulates in the bloodstream to toxic levels, causing the disulfiram-like reaction. This interaction also applies to alcohol-containing mouthwashes, some cough syrups, and topical alcohol preparations.
Data sourced from the US Food and Drug Administration (FDA) drug label database: FDA metronidazole drug label — disulfiram-like reaction with alcohol; OpenFDA drug label data.
Who should be careful?
Everyone taking metronidazole or tinidazole. Also be aware of hidden alcohol in medications, mouthwashes, and cooking sauces. This reaction applies even to small amounts of alcohol.
What if I've already taken Metronidazole and Alcohol?
If you have taken metronidazole and drunk alcohol and feel very unwell (flushing, vomiting, rapid heart rate, dizziness), rest quietly. Drink water. If symptoms are severe or you have a heart condition, call 999 or go to A&E.
Not sure if this combination is safe for your specific situation?
Speak to a pharmacist online — get personalised advice in minutes.
Speak to a pharmacist online →Service provided by independent online pharmacy partners.
⭐ Recommended on Amazon
Alcohol-Free Drinks Variety Pack
Great-tasting alternatives so you can still enjoy a drink while on medication.
View on Amazon →Mood Journal Notebook
Track how you feel day-to-day — especially useful when managing medication and lifestyle changes.
View on Amazon →Mindfulness Journal
Practical prompts to support mental wellbeing, especially when cutting back on alcohol.
View on Amazon →Affiliate links below. As an Amazon Associate we earn from qualifying purchases at no extra cost to you.
Frequently Asked Questions
Can I drink alcohol on metronidazole?
Absolutely not. Even small amounts of alcohol cause a severe reaction with metronidazole. Avoid alcohol completely during treatment and for 48 hours after the last dose.
What happens if you drink on metronidazole?
You will likely experience intense flushing, severe nausea and vomiting, headache, rapid heart rate, and feeling extremely unwell. This is a disulfiram-like reaction caused by acetaldehyde accumulation.
How long after metronidazole can I drink?
Wait at least 48 hours (2 days) after your last metronidazole dose before drinking any alcohol.
Does mouthwash cause a reaction with metronidazole?
Yes. Alcohol-containing mouthwashes can trigger a reaction. Use alcohol-free mouthwash during your metronidazole course and for 48 hours after finishing.