Omeprazole — Drug Interactions, Alcohol & Pregnancy Guide

Last reviewed: · Source: US FDA drug label database

About Omeprazole

Omeprazole is a proton pump inhibitor (PPI) used to reduce stomach acid. It is available over-the-counter (10mg, 20mg) and on prescription (40mg). It is one of the most commonly prescribed drugs in the UK.

Also sold as: Losec, Prilosec

Drug class Proton Pump Inhibitor (PPI)
Used for GORD / acid reflux, Stomach ulcers, H. pylori eradication (part of triple therapy), NSAID-induced gastric protection
Max adult dose 20-40mg once daily
OTC in UK Yes

Omeprazole and Alcohol

🟡 USE WITH CAUTION

Use with caution — alcohol irritates the stomach omeprazole is treating, and may slightly increase omeprazole levels in the body.

Full guide →

Omeprazole in Pregnancy

🟡 USE WITH CAUTION

Omeprazole is sometimes used in pregnancy for severe heartburn but requires medical advice — particularly in the first trimester.

Full guide →

Omeprazole — Drug Combinations

🟡
Omeprazole + Clopidogrel
Omeprazole can make clopidogrel less effective at preventing clots — the FDA adv…
🟡
Omeprazole + Levothyroxine
Long-term omeprazole can reduce levothyroxine absorption — take levothyroxine on…
🟡
Omeprazole + Citalopram
Omeprazole raises citalopram blood levels, which increases the risk of QT heart-…
🟢
Omeprazole + Metformin
Metformin and omeprazole are safe to take together — millions of people with dia…

⭐ Recommended on Amazon

⭐ Top Pick · Recommended on Amazon

Weekly Pill Organiser

Keep track of multiple medications with a clear 7-day pill box — reduces missed and double doses.

View on Amazon →
Recommended on Amazon

Medication Record Book

Log your medications, doses and times to stay safe and flag any concerns to your pharmacist.

View on Amazon →
Recommended on Amazon

Lockable Medicine Cabinet

Store all your medications safely in one place, out of reach of children.

View on Amazon →

Affiliate links below. As an Amazon Associate we earn from qualifying purchases at no extra cost to you.

👨‍⚕️

Not sure if Omeprazole is safe with your other medications?

Speak to a pharmacist online →