Naproxen — Drug Interactions, Alcohol & Pregnancy Guide

Last reviewed: · Source: US FDA drug label database

About Naproxen

Naproxen is an NSAID available over-the-counter (Aleve, 220mg) and on prescription (up to 1000mg/day). Its longer half-life (12-17 hours) means twice-daily dosing. Like ibuprofen, it carries GI and cardiovascular risks.

Also sold as: Naprosyn, Aleve, Feminax Ultra

Drug class NSAID
Used for Pain relief, Inflammation, Period pain, Arthritis, Gout
Max adult dose 500mg twice daily (prescription); 220-440mg OTC
OTC in UK Yes

Naproxen and Alcohol

🟡 USE WITH CAUTION

Avoid alcohol with naproxen — like ibuprofen, both irritate the stomach lining and together increase the risk of bleeding ulcers.

Full guide →

Naproxen in Pregnancy

🔴 AVOID

Avoid naproxen in pregnancy — like all NSAIDs it risks fetal kidney and heart complications, especially from 20 weeks onwards.

Full guide →

Naproxen — Drug Combinations

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Not sure if Naproxen is safe with your other medications?

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