Tramadol — Drug Interactions, Alcohol & Pregnancy Guide

Last reviewed: · Source: US FDA drug label database

About Tramadol

Tramadol is a prescription-only opioid with additional serotonin-noradrenaline reuptake inhibiting activity. It is a Class C controlled drug in the UK. It carries significant risks when combined with SSRIs (serotonin syndrome) and alcohol (respiratory depression).

Also sold as: Ultram, Tramacet (with paracetamol), Zydol

Drug class Opioid analgesic / SNRI
Used for Moderate to severe pain, Neuropathic pain
Max adult dose 50-100mg every 4-6 hours, maximum 400mg in 24 hours
OTC in UK Prescription only

Tramadol and Alcohol

🔴 AVOID

Never mix tramadol and alcohol — the combination can cause dangerous respiratory depression and significantly increases overdose risk.

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Tramadol in Pregnancy

🔴 AVOID

Avoid tramadol in pregnancy — prolonged use causes neonatal withdrawal, and use near delivery risks breathing problems in the newborn.

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Tramadol — Drug Combinations

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Not sure if Tramadol is safe with your other medications?

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